Scientists' quest to potentially neutralize the new coronavirus has been unrelenting. This time, the results of a study show that they found an antibody that prevents and treats covid-19 and the variants cataloged by Science.
The discovery was made by an international consortium of scientists, with the participation of experts the Karolinska Institute in Sweden. The study was published in the journal Nature.
The researchers were able to create a bispecific antibody, starting the junction of two natural antibodies.
The first tests had great results and the group of researchers will now set out to transform the compound into possible substances for treatment.
Natural antibodies were collected patients recovered Covid-19. Pre-clinical tests on mice have shown that this artificial molecule attacks the virus in two places at the same time.
The application is made by injection and it took only one dosage to notice a significant reduction in the viral load in the lungs of the animals. Inflammation caused by the virus has also reduced.
In the study, the scientists explain that, unlike parental antibodies, the bispecific “prevents detectable S binding to the Angiotensin 2 Conversion enzyme (ACE2), the cell receptor of the virus. In addition, it neutralizes Sars-CoV-2 and its variants of concern, as well as the escape mutants generated by parental monoclonals ”.
This type of test is already very common to fight some types of cancer and has now been tested against Covid-19.